novavax’s-covid-19-vaccine-is-effective,-but-less-so-with-some-versions

A COVID-19 vaccine made by Novavax is about 89 percent effective against disease, however doesn’t protect also versus an infection variation that arose in South Africa. The information likewise recommend that people who formerly had coronavirus infections might not be unsusceptible to the South Africa variant, known as 501 Y.V2 or B. 1.351, which is now circulating in at least 30 nations.

The results came the exact same day that health officials reported the first two U.S. cases of COVID-19 triggered by the South Africa variation.

Novavax Inc., based in Gaithersburg, Md., provided the interim data from medical trials in South Africa and the United Kingdom in a news release January 28.

Novavax’s vaccine, given in 2 shots 21 days apart, includes a rod-shaped nanoparticle studded with the coronavirus’s spike protein. It is the first protein-based COVID-19 vaccine for which there are efficiency outcomes.

In the United Kingdom, the company did a Stage III clinical trial to evaluate the vaccine’s efficacy against a placebo in more than 15,000 people. Of the 62 cases of COVID-19 that occurred among research study participants, 56 were in the placebo group and 6 in the vaccine group.

Those data show that the vaccine safeguards against severe disease with 89.3 percent efficiency. The vaccine protected almost as well– with 85.6 percent efficiency– against disease from a more transmissible variation of the infection known as B. 1.1.7 that has become popular in the United Kingdom ( SN: 12/22/20).

The South African trial included about 4,400 grownups. As the trial began, a variation of the coronavirus called 501 Y.V2 became the predominant variation in the nation. That variation is of issue because some proof suggests it can escape antibodies that prevent the virus from going into cells ( SN: 1/27/20).

The vaccine showed 60 percent effectiveness at preventing extreme COVID-19 in individuals who are HIV-negative. When HIV-positive individuals were added to equation, the vaccine was 49.4 percent effective at preventing illness.

Researchers have actually determined the hereditary makeup of the infection in 27 of the 44 cases in the research study. The 501 Y.V2 variant represented 25 of those 27 cases, or 92.6 percent.

About a third of the participants had antibodies in their blood at the start of the study indicating that they ‘d had previous infections with SARS-CoV-2, the infection that causes COVID-19 Those previous infections didn’t secure against the brand-new variation.

” The wave one health problem experience is not providing immunity to wave two,” Gregory Glenn, president of research study and development for Novavax said January 28 throughout a teleconference with financiers.

Still, the business is motivated that the vaccine showed some defense against the variation, Glenn said. Other business are testing whether their vaccines can likewise avoid health problem triggered by the new variation.

Novavax already has brand-new variations of its vaccine, including one that includes the 501 Y.V2 version, in development and expects to begin scientific trials in the 2nd quarter of 2021, Glenn stated.


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